These drugs havent been directly compared in clinical studies. This can cause gallstones (hardened stones in your gallbladder). Medications in this class prevent your small intestine from absorbing cholesterol. This drug has not been studied in pregnant females.*. Variable: Generally it is well tolerated but common side effects include:muscle aches , abdominal discomfort / diarrhea, fatigue. But it may be a sign that your liver isnt working as well as it should. If you and your doctor decide that Zetia treatment isnt right for you, you simply wont take any more doses. Learn more about some of the side effects that Zetia may cause. Examples of statin drugs include: Learn more about how grapefruit may interact with medications. Increased liver enzyme levels are a possible side effect of Zetia. If you think youve taken too much of this drug, call your doctor. If you have liver problems, your liver may not work properly to remove medications such as Zetia from your body. This is not a complete list of side effects and others may occur. Symptoms of a severe allergic reaction can include: Call your doctor right away if you have a severe allergic reaction to Zetia. Depending on your age or other medical conditions you may have, you may be at higher risk of developing rhabdomyolysis while taking Zetia. Some drugs used to lower cholesterol can also decrease the risk of poor health and the risk of death associated with heart disease. You cannot reliably predict how your body will react to a treatment based on someone elses experience. Drugs in this class prevent your small intestine from absorbing cholesterol. Zetia is sometimes used with medications in the statin drug class. (Fenofibrate is a drug used to lower your triglyceride levels.). Temporary excursions of 59F to 86F (15C to 30C) are allowed. They may suggest foods that can help lower your cholesterol and reduce your risk of weight gain. For more information, see the Precautions section below. However, it isnt known how Zetia may affect these risks. POTS was also linked, to a lesser degree, to Covid vaccination with an mRNA vaccine, according to the new study. Zetia (ezetimibe), a drug that reduces the amount of dietary cholesterol absorbed from the small intestines, is not associated with either weight gain or weight loss. It belongs to a class of drugs called cholesterol absorption inhibitors. Zetias mechanism of action is considered complementary to that of statins and fenofibrate. This can cause Zetia to be less effective. These drugs havent been directly compared in clinical studies. For this purpose, Zetia is used with a low-cholesterol diet (but with no other drugs) in adults and in children ages 10 years and older. Your side effect notes can include things such as: Keeping notes and sharing them with your doctor will help your doctor learn more about how Zetia affects you. If you have questions about the differences between Zetia and statin drugs, talk with your doctor. Zetia is meant to be used as a long-term treatment. This active drug is also available as a generic medication. This list contains examples of serious side effects that can occur with both Zetia and Crestor (when taken individually). They often originate at the base of the skull and spreading on the back of the head and neck. You can take Zetia with or without food. The children took Zetia and simvastatin or simvastatin alone. A malfunctioning ANS is sometimes called 'dysautonomia'. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. They can both be taken with or without food. * For these purposes, Zetia and Crestor are used to treat people of different ages. You may wonder how often certain side effects occur with this drug, or whether certain side effects pertain to it. Other drugs are available that can treat your conditions. Can diet help improve depression symptoms? You may experience muscle problems as a side effect of Zetia. The generic form of Zetia costs about the same as the generic form of Lipitor. Tell your doctor if youre experiencing bothersome side effects from Zetia. People who may be at higher risk of this side effect include those who: Tell your doctor if any of the above apply to you before starting Zetia treatment. In the video she posted on Thursday, the "Real Housewives of New York City" alum detailed her suffering from a severe dehydration issue and shared that her doctor . If your muscle-related side effects dont go away or become severe, tell your doctor right away. Use of the terms male and female in this article refers to sex assigned at birth. Plant sterols are similar to cholesterol. Rhabdomyolysis can also occur with statin drugs, and you may need to take Zetia with a statin. Statins are another type of medication used to lower cholesterol. Some people experience mild side effects with Zetia. These tests will look at your cholesterol levels and also your liver enzyme levels. The following information describes dosages that are commonly used or recommended. If youre currently taking cyclosporine, talk with your doctor about whether its safe for you to take Zetia. Zetia (ezetimibe) is a prescription drug used to treat certain types of high cholesterol in adults and children. Zetia may stay in your system for several days after you stop taking it. dark colored urine. Get answers to some frequently asked questions about Zetias side effects. A large review by the American Heart Association compared studies of CoQ10. It isnt known how long adults and children experienced diarrhea while taking Zetia in these clinical studies. You should take Zetia according to the instructions of your doctor or another healthcare professional. Note: Some of the drugs listed here are used off-label to treat these specific conditions. Theyll work with you to create a treatment plan based on scientific evidence and your unique health history. Despite having lower total cholesterol than white people, African Americans are at greater risk of dying from heart disease. Zetias effect on cardiovascular morbidity and mortality isnt known. Others may experience GI issues in conjunction with other symptoms, such as fainting. So if youre taking Zetia with a statin drug, you may need to avoid eating grapefruit or drinking grapefruit juice during your treatment. Read more about these alternatives to traditional statin, Having high cholesterol puts you at risk for a heart attack or stroke. Zetia comes as a tablet that you swallow. Created for people with ongoing healthcare needs but benefits everyone. It can also interact with certain supplements as well as certain foods. We've provided a list of the best at-home tests for. They can suggest ways to help relieve this side effect. Females who could become pregnant should use birth control while taking Zetia with a statin drug. Sharing this information can help you avoid potential interactions. However, studies have found both Zetia and Lipitor to be effective for lowering cholesterol. Do my other medications increase my risk of side effects with Zetia? You can also call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. Or they may recommend a product you apply to your skin, such as hydrocortisone cream. Postural orthostatic tachycardia syndrome (POTS) is one of a group of disorders that have orthostatic intolerance (OI) as their primary symptom. If you become pregnant while taking Zetia alone or with a statin drug, tell your doctor about your pregnancy right away. However, side effects are generally mild and go away as the body adjusts to the medication. Most of Zetias side effects should go away within a few days or weeks. Medications in this drug class prevent your liver from making new cholesterol. Porphyrias are rare, mainly genetic disorders that affect the body's ability to make hemoglobin. Forget HDL and LDL. Statins are commonly prescribed with Zetia to treat certain types of high cholesterol. Porphyria patients are often overly sensitive to sunlight. Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. Zinnia elegans 'Benary's Giant Golden Yellow'. Learn about alternatives like new drugs, A new class of self-injectable medications are showing promise in treating high cholesterol. Leqvio is a prescription drug used to lower cholesterol. Cholestyramine (Prevalite) is a drug used to treat high cholesterol. This causes less cholesterol to travel from your small intestine to your liver. This included relief of muscle pain, muscle weakness, and cramps. Based on animal studies, Zetia may cause harm to the fetus when taken by a pregnant woman. If you have unused medication that has gone past the expiration date, talk to your pharmacist about whether you might still be able to use it. High cholesterol may be caused by genetics, smoking, low amounts of physical activity, or eating too many high-cholesterol foods. When you get Zetia from the pharmacy, the pharmacist will add an expiration date to the label on the bottle. These can be signs of rhabdomyolysis (muscle breakdown), which is a serious medical condition. The Benary's Giants have large, double blossoms, 4 to 6 inches across, available in a rainbow of . They can both be taken with or without food. However, you shouldnt stop taking Zetia without first talking with your doctor. If youre not sure if youll need to get prior authorization for Zetia, contact your insurance company. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre using Zetia. Talk with your doctor if you experience diarrhea while taking this medication. Zetia and Lipitor have some similar side effects and others that vary. The absence of symptoms doesn't necessarily mean that the cause of POTS is gone as well. Here is a list of conditions that the Food and Drug Administration (FDA) has approved Zetia and Lipitor to treat. 6. Zetia can also be used with statin drugs in adults. They may have suggestions depending on your weight and health goals. Zetia is sometimes used with medications in the statin drug class. Less commonly, taking Zetia may lead to serious side effects. Crestor is part of the statin drug class. Examples of statin drugs include atorvastatin (Lipitor) and simvastatin (Zocor). POTS is a form of orthostatic intolerance that is associated with the presence of excessive tachycardia and many other symptoms upon standing. You can use the study as a second opinion to make health care decisions. The brand name for this drug combination is Vytorin. joint or muscle pain*. If you and your doctor determine that Zetia is safe and effective for you, youll likely take it long term. For more information, see the How Zetia works section below. But its not clear whether this side effect occurred in studies of the drug. Lipitor is an HMG-CoA reductase inhibitor (a "statin" drug) and Zetia is a cholesterol -lowering drug. Clinical studies have shown Zetia to be effective for treating homozygous familial hypercholesterolemia when used with atorvastatin or simvastatin. (Mixed hyperlipidemia is also known as mixed high cholesterol.). Zetia has a well-documented safety profile. Both Zetia and Lipitor come as tablets that are swallowed. Lipitor is also FDA-approved for the following conditions when used with a low-cholesterol diet: primary dysbetalipoproteinemia in adults (a genetic condition that causes high total cholesterol, high triglycerides, and low HDL levels), liver complications, such as high levels of, Both Zetia and Crestor are FDA-approved to treat the following conditions* when used with a. Crestor is also FDA-approved for the following conditions in adults when used with a low-cholesterol diet: primary dysbetalipoproteinemia (a genetic condition that causes high total cholesterol, high triglycerides, and low HDL levels), pain on the right side of your body, below your ribs, in adults as monotherapy or in combination with an HMG-CoA reductase inhibitor (statin drug), in adults in combination with a fenofibrate, in combination with statins, in people with hepatic disease, in combination with statins, in people with elevated hepatic transaminases, in combination with statins, during pregnancy or in someone planning to become pregnant, in combination with statins, while breastfeeding, in people who have a known allergy to Zetia. Would a lower dose of Zetia help to reduce my risk of side effects? Talk with your doctor about birth control options that may be best for you. Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system, Leqvio side effects: What you should know, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, 2.4% of people who took a statin drug alone, 2.5% of people who took Zetia with a statin drug, 2.2% of people who took a statin drug alone, 3.2% of adults and children who took Zetia with a statin drug experienced muscle pain, 2.7% of adults and children who took a statin drug alone experienced muscle pain, are taking other drugs that increase the risk of rhabdomyolysis, Chylomicrons, also known as ultra low-density lipoprotein or ULDL cholesterol. In the studies, total cholesterol levels: To learn how Zetia and the placebo affected peoples levels of HDL (good) cholesterol, triglycerides, non-HDL cholesterol, and Apo B, see the prescribing information. If you develop increased liver enzyme levels, your doctor may make changes to your treatment plan. Below are medications that can interact with Zetia. Zetia may cause joint pain. Statins are drugs used to lower cholesterol. Most patients will need at least 64 to 80 ounces (8 to 10 cups) of hydrating liquids throughout the day, such as water, broth, juice, or decaffeinated tea. POTS affects the body's ability to pump blood from the legs to the rest of the body while standing. The manufacturer of Zetia hasnt stated whether the tablets can be crushed, split, or chewed. Your doctor might suggest one or more of these: fludrocortisone (helps the kidneys retain sodium) midodrine (causes the blood vessels to tighten) beta blockers (slow down the heart rate). In fact, researchers have looked into using Zetia to treat hair loss due to a condition called alopecia areata. However, you may need to avoid grapefruit if you take Zetia with a statin, another type of cholesterol medication. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. This is because fenofibrate is the only fibrate Zetia was studied with, so it isnt known whether Zetia and other fibrate drugs are safe to use together. Zetia can cause mild or serious side effects. Common side effects may include: diarrhea; cold symptoms such as stuffy nose, sneezing, sore throat; pain in an arm or leg; joint pain; or. 5.8k views Answered >2 years ago. More common side effects in people taking Zetia* include: * In studies, these side effects were reported in people who took Zetia by itself. In order to diagnose POTS, your doctor will need to measure your heart rate when you are sitting at rest. There arent any herbs or supplements that have been specifically reported to interact with Zetia. However, animal studies dont always predict what will happen in humans. * Sex and gender exist on spectrums. Talk with your doctor about your health history before you take Zetia. It can cause mild side effects and, less commonly, serious side effects. Taking Zetia with cholestyramine can decrease the amount of Zetia in your body. Total cholesterol was reduced by 12% more in children who took Zetia and simvastatin than children who took simvastatin alone. Zetia can interact with several other medications. If you have a history of heavy alcohol use and are taking Zetia with a statin drug, you may have a higher risk of side effects. Zetia is primarily cleared from the body through fecal excretion. Phil Fischer, M.D., medical director of Mayo Clinic's children's hospital and a POTS specialist, led . (For more information on the specific conditions Zetia can treat, see the Zetia uses section.). If the side effects seem life threatening or if you think youre having a medical emergency, immediately call 911 or your local emergency number. Bock's fainting spells are one of the hallmarks of POTS. They may want to select a different treatment option for you. Zetia does not cause an increase or a decrease in blood pressure. However, excessive alcohol use can damage your liver over time. tender, swollen glands in neck. POTS is an unusual condition in which your heart rate speeds up by 30 or more beats per minute with little or no change in blood pressure. However, skip your missed dose if its almost time for your next dose. Dr. John Szawaluk answered. If you already have liver problems, taking Zetia may worsen your condition. The dose of Zetia used for children is the same as the adult dose. Zetia belongs to a class of drugs called cholesterol absorption inhibitors. The following lists contain some of the key side effects that may occur while taking Zetia. They can suggest ways to help relieve your side effects, or they may recommend a different treatment option for you. But if you have any symptoms that are ongoing or that bother you, talk with your doctor or pharmacist. Pots or postural tachycardia syndrome is, also known as postural orthostatic tachycardia syndrome, is a condition that affects the flow of blood in the heart and brain. If you have joint pain while taking Zetia, you may also experience swelling, redness, or weakness in your joints. Ezetimibe can cause the breakdown of muscle tissue . Talk with your doctor about any liver problems you may have and whether its safe for you to take Zetia. Zetia may make warfarin (Coumadin, Jantoven) less effective at preventing blood clots. Occur with statin drugs include atorvastatin ( Lipitor ) and Zetia is primarily cleared from the pharmacy the. 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